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Because of this, tissue concentrations are significantly higher than are plasma concentrations. Azithromycin is distributed widely into brain tissue however, not into cerebrospinal fluid or the aqueous humor of the eye. Protein binding varies with plasma concentration; 51% of the drug is bound at low concentrations (0.02 mcg/ml) which binding decreases to 7% at higher concentrations (2 mcg/ml). Azithromycin has a long half-life in both adults and children , which is partially explained by its considerable tissue uptake and slow release. Elimination is largely in the feces, following excretion in to the bile, with less than 14% excreted in the urine. 250 to 500 mg PO 3 days per week has been recommended to lessen exacerbation rates.

Prescribing ZITHROMAX in the lack of a successful or strongly suspected bacterial infection is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Local IV site reactions have been reported with the intravenous administration of azithromycin. The incidence and severity of these reactions were the same when 500 mg azithromycin was given over one hour (2 mg/mL as 250 mL infusion) or higher 3 hr (1 mg/mL as 500 mL infusion) . All volunteers who received infusate concentrations above 2.0 mg/mL experienced local IV site reactions and, therefore, higher concentrations should be avoided.

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ZITHROMAX and other medicines may affect each other creating side effects. ZITHROMAX may affect the way other medicines work, and other medicines may affect how ZITHROMAX works. Contact your doctor immediately if you are giving ZITHROMAX to a young child and he or she vomits or becomes irritable when fed. have a history of cholestatic jaundice or hepatic dysfunction that happened by using azithromycin. Pharmacokinetic parameters in older volunteers were just like those in young adults for the 5-day therapeutic regimen.

Don’t stop taking this medicine, even if your symptoms subside. You must learn to feel better within a few days of taking azithromycin, but this will rely upon the type of infection you have. Follow all directions on your prescription label and read all medication guides or instruction sheets. The product information provided by this web site is intended just for health care professionals, patients, consumers and caregivers in the United States. The merchandise discussed herein may have different product labeling in several countries.

Advise women to monitor breast-fed infant for diarrhea, vomiting, or rash. Assess patient for skin rash frequently during therapy. Discontinue azithromycin initially sign of rash; may be life-threatening. Stevens-Johnson syndrome or toxic epidermal necrolysis may develop.